Adenine Aminohydrolase
نویسندگان
چکیده
منابع مشابه
Adenine aminohydrolase. An investigation of specificity.
In addition to their action upon adenine, the adenine aminohydrolases of Azofobacfer vinelandii and of Candida ufilis have been found capable of acting upon 6-chloropurine, 6-iodopurine, 6-hydrazinopurine, 2-amino-6-chloropurine, 2,6-diaminopurine, and 7-aminothiazolo[5,4-dlpyrimidine. In each case the enzyme catalyzes the replacement by a hydroxyl group of the substituent on position 6 or on t...
متن کاملInteraction of AMP-aminohydrolase with myosin and its subfragments.
We have shown that purified rabbit skeletal muscle AMP-aminohydrolase binds to rabbit muscle myosin, heavy meromyosin, and Subfragment 2 but does not bind to light meromyosin nor to Subfragment 1. The dissociation constant for binding to myosin was determined to be 0.14 muM. A new sedimentation boundary, presumably reflecting formation of a complex between AMP-aminohydrolase and heavy meromyosi...
متن کاملActivation of AMP aminohydrolase during skeletal-muscle contraction.
AMP aminohydrolase activity is enhanced by 60% after 5 s tetanic stimulation of phosphorylase kinase-deficient mouse muscle and after 60 s tetanus in normal mice. During the recovery from tetanus the activity in the contralateral leg is similarly enhanced. The activation is stable to 1000-fold dilution and has a half-life of approx. 1 h.
متن کاملTrypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity☆
African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo and import purines from their hosts to build nucleic acids. The purine salvage pathways of Trypanosoma brucei being redundant, none of the involved enzymes is likely to be essential. Nevertheless they can be of pharmacological interest due to their role in activation of purine nucleobase or nucleoside ...
متن کاملModeling of the hydration shell of Adenine
The molecular geometry of complex of adenine with 8 water molecules was calculated with Hartree-Fock (HF). The standard 6-31G(d) basis set has been employed. The existence of C-H…O Hydrogen bonds between the water molecules and the hydrophobic part of nucleobase is stablished. We optimized structures and computed interaction energies of all complexes of adenine with water molecules step by step...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1967
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)99458-5